ADAPTATION MEASURES FOR SMART CITY PROJECTS IN SPAIN FOR THE COVID-19 PANDEMIC AND THE NEW GLOBAL SOCIO-SANITARY SCENARIO

The COVID-19 pandemic has had a major impact on the development and functioning of cities around the world and on people's daily lives, bringing with it significant challenges for future urban development plans. In Spain, in 2018 the government launched the National Plan for Smart Territories, which in turn was made up of the call for Smart Tourist Destinations and Smart Buildings. After evaluating various smart city initiatives, 33 entities and local groups, including city councils and county councils, were beneficiaries. This communication will detail the scope changes made in some of these projects during the period of drafting technical specifications and start of execution as a result of the outbreak of the COVID-19 health crisis, ruling out actions considered to have less impact on citizenship for solutions focused mainly on controlling the influx of people in public places. In addition, emerging technologies and applications are analyzed to prevent COVID-19 and reduce its impact on smart cities, such as network architecture security, data authentication and preservation, Internet of Things (IoT). © 2022 by the authors. Licensee AEIPRO, Spain.

Europe and the economic "lessons” of covid-19: Ecofeminism and development alternatives

This chapter addresses the scenarios that are opening up in Europe, using two complementary prisms to structure our ideas. It analyses the European Union (EU) measures that have been implemented and the resulting advances as well as criticisms raised from the feminist sectors. The chapter examines other strategies of feminist resistance and struggle that allow progress towards Life Sustainability as an emancipatory horizon and a new way of organizing the economic system. The feminist factions demanded: On the one hand, to overturn the austerity policy, with a progressive tax reform that did not favour the male provider/female caregiver family model and that fought against tax fraud. Gender equality has always been a constituent part of the European Social Model but not always with the same focus. A green transition that tries not to leave anyone behind in the short term should not forget the transformation horizons in the long term. © 2022 selection and editorial matter, Fernando López-Castellano, Carmen Lizárraga and Roser Manzanera-Ruiz;individual chapters, the contributors.

Bovine reproductive and productive parameters in milk production systems during times of COVID 19

In order to analyze changes in bovine reproductive and productive parameters in dairy herds because of the COVID -19 pandemic, an investigation was carried out in the Province of Santo Domingo de los Tsachilas, Costa Region, Ecuador. To collect the information, research techniques (surveys, structured interviews and group sessions) were used from 86 producers belonging to the Producers Province Association. Where the variables were studied: age at first service (EFS), age at first calving (EFC), types of service (TS), age at weaning (EW) and milk production (ML) before and during COVID-19. The data collected were compared using Chi square tests and the likelihood ratio. The PL was compared with the Student's t-test for paired samples. The EPS, EPP and ED were not significant;but, an increase in the proportion of natural mounts (P<0.01) of 36 % was observed, to the detriment of artificial insemination. There was a decrease in ML (P<0,01) from 8.3 to 8.0 litres.cow(-1). In conclusion, the pandemic caused by COVID-19 has negative consequences on milk production systems.

A CASE OF TRACHEOBRONCHIAL AMYLOIDOSIS PRESENTING AS SYNCOPE

SESSION TITLE: Systemic Diseases with Deceptive Pulmonary Manifestations SESSION TYPE: Rapid Fire Case Reports PRESENTED ON: 10/18/2022 12:25 pm - 01:25 pm INTRODUCTION: Amyloidosis of the respiratory tract is rare. We present a case of tracheobronchial amyloid presenting as multifactorial cough with syncope. CASE PRESENTATION: The patient is a 65-year-old man with history of hypertension, hyperlipidemia, and allergic rhinitis who presented to the ED after a syncopal event. Two weeks prior, he had a new-onset myalgias and severe persistent cough, not resolving with over-the-counter medications. During a coughing paroxysm, he experienced a brief loss of consciousness. On arrival, his vital signs and physical exam were within normal limits except for Mallampati II, BM of 38.8 kg/m2. Basic laboratory testing was also unremarkable except for troponin T of 251 nl/dL and NT-ProBNP of 1181 pg/mL. NP swab for Sars-CoV-19 (PCR), Influenza A and B were not detected. CT of the chest revealed an area of circumferential mural soft tissue thickening in the left lower lobe bronchi. Cardiac MRI showed an area of subepicardial delayed enhancement, suggestive of myocardial inflammation or edema. Flexible bronchoscopy confirmed that the left lower lobe bronchus and proximal subsegmental bronchi had an infiltrative process with a friable, erythematous irregular mucosal surface. Forceps biopsy sampling and staining with Congo red, sulfate Alcian blue and Trichome stain were positive for amyloid deposits. Immunostain revealed predominantly CD3 positive T-Cells. Mass spectometry showed AL (lamda)-type amyloid deposition. GMS and AFB stains were negative. Telemetry showed 2-3 second pauses, correlated with episodes of cough. DISCUSSION: Amyloidosis is a disorder caused by misfolding of proteins and fibril accumulation in the extracellular space. It can present as a diffuse or localized process to one organ system. Several patterns of lung involvement have been described: nodular pulmonary, diffuse alveolar-septal, cystic, pleural, and tracheobronchial amyloidosis. Tracheobronchial amyloidosis is usually limited and not associated with systemic disease or hematologic malignancy. It can be asymptomatic, or can present with cough, dyspnea or signs of obstruction, including postobstructive pneumonia. Congo Red stained samples reveal green birefringence under polarized light microscopy. Further analysis of proteins usually reveals localized immunoglobulin light chains (AL). Cough syncope is due to increased intrathoracic pressure, decreased venous return and cardiac output, stimulation of baroreceptors, decreased chronotropic response, arterial hypotension and decreased cerebral perfusion. Our patient presented with multifactorial cough (possible viral infection, upper airway cough syndrome, amyloidosis) causing sinus pauses and syncope, on underlying myocarditis. CONCLUSIONS: Amyloid infiltration of the respiratory system is rare, but it should be considered in the differential diagnosis of airway disorders, nodular or cystic lung diseases, and pleural processes. Reference #1: Milani P, Basset M, Russo F, et al. The lung in amyloidosis. Eur Respir Rev 2017;26: 170046 [https://doi.org/10.1183/16000617.0046-2017]. Reference #2: Utz JP, Swensen SJ, Gertz MA. Pulmonary amyloidosis. The Mayo Clinic experience from 1980 to 1993. Ann Intern Med. 1996 Feb 15;124(4):407-13. doi: 10.7326/0003-4819-124-4-199602150-00004 Reference #3: Dicpinigaitis PV, Lim L, Farmakidis C. Cough syncope. Respir Med. 2014 Feb;108(2):244-51. doi: 10.1016/j.rmed.2013.10.020. Epub 2013 Nov 5. PMID: 24238768. DISCLOSURES: No relevant relationships by Amarilys Alarcon-Calderon No relevant relationships by Ashokakumar Patel

LONG TERM USE OF ANTICOAGULATION IN CVT IN A TERTIARY HOSPITAL

Background and aims: Anticoagulation use on CVT is followed until 6 to 12 months according to guidelines. Longer periods of treatment are used in patients with high thrombotic risk. We describe the duration of treatment with OAC and what risk factors are related to longer treatment. Methods: We conducted a retrospective single centre study in a tertiary hospital in México City. Electronic medical files of consecutive patients with CVT were reviewed from January 2018 to June 2020. Clinical, radiological and laboratory variables were obtained. Patients were allocated according to the time of use of OAC (less or more than a year). Results: We collected data from 20 patients. 14 (70%) were female, with a mean age of 33.5 (26-50). 40% (n=8) were smokers, 20% (n=4) used hormonal contraceptives, 15% (n=3) were pregnant or in puerperium and 10% (n=2) referred vaccination for SARS-CoV-2. Superior sagittal sinus was the most frequently affected (65%). The median time of AOC treatment was 13 months (6.7-16.7). In the bivariate analysis, the existence of a chronic cause (OR 14;IC95%, 1.25 - 156;p= 0.028), and prolonged hospitalization (OR 15.7;IC95% 1.7 - 141.4 p= 0.22) were associated with AOC treatment over a year. Initial NIHSS, mRS at discharge, D-dimer values, or seizures at presentation showed no correlation. Conclusions: Use of OAC in a tertiary centre is related to chronic conditions with high thrombotic risk and with long hospital stay, according to the guideline's recommendations. (Table Presented).

Spatiotemporal Surveillance of SARS-CoV-2 in the Sewage of Three Major Urban Areas in Peru: Generating Valuable Data Where Clinical Testing Is Extremely Limited

Peru has been severely affected by the COVID-19 pandemic. By January 2022, Peru had surpassed 200 000 COVID-19 deaths, constituting the highest death rate per capita worldwide. Peru has had several limitations during the pandemic: insufficient testing access, limited contact tracing, a strained medical infrastructure, and many economic hurdles. These limitations hindered the gathering of accurate information about infected individuals with spatial resolution in real time, a critical aspect of effectively controlling the pandemic. Wastewater monitoring for SARS-CoV-2 RNA offered a promising alternative for providing needed population-wide information to complement health care indicators. In this study, we demonstrate the feasibility and value of implementing a decentralized SARS-CoV-2 RNA wastewater monitoring system to assess the spatiotemporal distribution of COVID-19 in three major cities in Peru: Lima, Callao, and Arequipa. Our data on viral loads showed the same trends as health indicators such as incidence and mortality. Furthermore, we were able to identify hot spots of contagion within the surveyed urban areas to guide the efforts of health authorities. Viral decay in the sewage network of the cities studied was found to be negligible (<2%). Overall, our results support wastewater monitoring for SARS-CoV-2 as a valuable and cost-effective tool for monitoring the COVID-19 pandemic in the Peruvian context.

Design and Evaluation of the BeArS@home and Slugs@home Choose-Your-Own-Adventure-Style Online Laboratory Experiments

The COVID-19 pandemic has emphasized the importance of designing effective methods for remote teaching. At the University of California, Berkeley, and the University of California, Santa Cruz, instructors adapted to the necessity of remote laboratory instruction by creating choose-your-own-Adventure-style video-based online experiments introduced to thousands of students across 11 different courses. These experiments are designed to provide students with the opportunity to make and receive feedback on experimental decisions and learn from common mistakes that they may have encountered in hands-on laboratory instruction. Students' and instructors' impressions of the online experiments and student learning outcomes in both online and traditional laboratory courses were assessed using surveys, focus groups, and interviews via a mixed-methods approach. Though most respondents (79%) did not agree that online laboratory instruction was as effective as in-person instruction, the majority agreed that the online experiments were clear and easy to follow (75%), interesting and engaging (52%), and helpful for learning about lab techniques (70%) and the concepts underlying these techniques (77%). Many also mentioned benefits of online laboratory instruction, including flexibility in scheduling and an increased focus on conceptual learning. Assessments of student learning also suggested that students who took the course online learned as much conceptually as students who had previously completed the course in-person. The results of this study highlight the positive and negative aspects of this type of interactive online laboratory instruction, which could help inform the design of future lab experiences whether they take place in an online, hybrid, or in-person environment. ©

USING THE ECODESIGN IN SUMMER CHILDREN'S CAMPS

At the University of Malaga, through its General Foundation (FGUMA), summer camps are oferted for the children of the university community members. In the pre-COVID summer, a pilot experience was carried out in the proposal of the different activities of the camp aimed at the creative construction of final products by reusing and recycling materials. To plan these activities, a group from the School of Industrial Engineering with experience in ecodesign joined the organizing team. The proposal had the support of the Vicerectorate of Smart Campus, which facilitated access to products that had finished their first useful life. For the design of sustainable activities, the following were taken into consideration: age, situation, needs of the area, execution times and materials available for reuse. In addition, a study of other similar previous experiences was carried out to assess the complexity of each proposal. The ecodesign group proposed different creative products adapting the tasks to the age groups and the time available for the development of each activity. The proposal implied several structures of the university, which developed a multidisciplinary work with different groups of children. The manufactured products will be used in the following editions of the camp. © 2021 by the authors

First report and genome sequencing of SARS-CoV-2 in a cat (Felis catus) in Colombia

Introduction. SARS-CoV-2 is a virus of zoonotic origin that can bind to ACE2 receptors on the cells of various mammals, including animals such as cats, dogs, ferrets, hyenas, coatis, otters, big cats, non-human primates, white-tailed deer, manatees, hippopotamuses, hamsters, and minks. Studies have shown that the virus can circulate among minks and Syrian hamsters, mutate, lead to animal-to-human zoonotic jump, and further onward spread between humans. The transmission of the virus from humans to cats is evident, but the virus's return to humans has not yet been demonstrated. Infection in pets is unusual, and there are few human-to-pet transmission reports worldwide. Objective. To describe the SARS-CoV-2 infection in Cordoba, Colombian Caribbean, a domestic animal. Methods. A cross-sectional molecular surveillance study was carried out, oral and rectal swabs were taken from cats and dogs living with people diagnosed with COVID-19. Results. SARS-CoV-2 was found in a cat living with a person with COVID-19. Genome sequencing showed that the B.1.111 lineage caused the infection in the cat. The owner's sample could not be sequenced. The lineage is predominant in Colombia, and this variant is characterized by the presence of the D614D and Q57H mutation. Conclusion.This is the first report on sequencing the SARS-CoV-2 genome in a cat in Colombia shows the importance of some interesting SARS-CoV-2 mutations in promoting the transmissibility of this new coronavirus in companion animals. Lack of information Human-to-cat or cat-to-human infection. © 2022, Fundacao Oswaldo Cruz. All rights reserved.

Relevance of Political Actions Aimed at Guaranteeing a Healthy and Sufficient Diet During and After the COVID-19 Pandemic in the context of Latin America

Unhealthy eating patterns are the main behavioral risk factor related to mortality in Latin America and the Caribbean. Because of the COVID-19 pandemic, the implementation of political actions to promote a healthy diet and reduce the consumption of ultra-processed foods is a priority, not only to prevent non-communicable diseases (NCDs), but also to reduce the clinical impairment of the persons who suffer them. The political actions that ensure the supply of unprocessed foods of high nutritional value to the markets in a periodic and timely manner and that allow the farmers to continue with their cultivation and harvest activities are a fundamental pillar to mitigate the effects of indirect health negatives derived from the pandemic. To face the growing challenge of obesity and NCDs associated with unhealthy eating patterns a comprehensive approach is required that includes the following actions: taxes on sugary beverages, restrictions on marketing and advertising of ultra-processed foods and beverages, front-of-package warning label, as well as policies to modify agricultural and food systems.

Nutritional energy in pos COVID-19 time in Peru

The current COVID-19 pandemic is a disease that affects everyone. The Peruvian government has promoted the use of physical barriers;however, the immune system is an important defense against the virus that has not yet been motivated. The objectives were: to know the COVID-19 disease and its behavior, to know the nutritional diet of the population;to define the population at risk and to make food proposals in time of pandemic in Peru. For this, we used the information sources of scientists and science institutions. The results were: the main characteristics of the disease and its effect on the population at different ages and risk groups;described the feeding in six different regions of Peru, showing high simple carbohydrate intake and unbalanced nutritional energy, identified the nutrients of the biodiversity resources;defined the population with the risk;presented a diet for patients at home, those in critical condition and those who passed the disease;as well as general recommendations to the population that includes a comprehensive energy to achieve a healthy life. Culminates highlighting the importance of the role of the Peruvian State to promote a healthy life for the population.

Prototype of an application for capacity monitoring in places of voting to prevent the spread of Covid-19

This research work is based on the problem of social distancing that will influence the next presidential elections in Peru, due to the global pandemic that is being experienced worldwide due to COVID-19 being the agglomeration of people one of the main causes of its spread. Faced with this problem, the development of the capacity control prototype has been proposed, to avoid the increase of contagions towards the health of citizens, in such a way it was developed through the four phases of the Rapid Development Methodology (RAD) which had as The result was the creation of prototypes carried out in Balsamiq and adobe XD, the results were obtained through surveys carried out by voting citizens, consulting their opinion of the prototypes shown as well as the importance of a capacity control application, these results can benefit all voting citizens since a capacity control will avoid the agglomeration of people avoiding infections. ©2021 Seventh Sense Research Group .

MASSIVE PULMONARY EMBOLISM TREATED WITH THROMBOLYSIS IN COVID-19: A CASE SERIES

SESSION TITLE: Medical Student/Resident Pulmonary Vascular Disease Posters SESSION TYPE: Med Student/Res Case Rep Postr PRESENTED ON: October 18-21, 2020 INTRODUCTION: Thromboembolism has been associated with respiratory syndrome coronavirus 2 (SARS-CoV-2). We present a case series of patients with SARS-CoV-2 with massive pulmonary embolisms (PE) treated with systemic thrombolysis. CASE PRESENTATION: A 63-year-old woman with schizophrenia presented the ED with acute deterioration in mentation. Five days prior, she had a positive COVID-19 RT-PCR on admission screening to a mental health facility. On arrival, she was tachycardic, hypoxemic, with respiratory distress rrequiring intubation. She also became hypotensive requiring vasopressors. A CT angiogram showed a large thrombus in the right pulmonary artery, extending into upper lobar and multiple segmental branches, as well as the interlobar artery. Multiple emboli at segmental level were found in the left lung, with signs of RV strain, also shown on echocardiogram (McConnell sign, RVSP 50-60). The PERT team was activated, and she received systemic thrombolysis and inhaled nitric oxide. In April and May of 2020, we treated 4 patients with COVID-19 complicated by massive PE, equally distributed among male and female sex. The mean age was 62 and 75% had risk factors for PE (smoking, HIV, obesity). Mean Wells score was 2.25 points and they were diagnosed on average 52 hours after presentation. 75% were on prophylactic enoxaparin (40 mg daily). They were hemodynamically unstable and ¾ had RV strain. Mean laboratory testing on diagnosis: D-dimer:9.21 mcg/ml;troponin:0.24 ng/ml (peak of 2.18);proBNP:1590 pg/mL;lactic acid:1.9 mmol/L. They received alteplase (50 mg, except for one patient, who required 100 mg), unfractionated heparin and transitioned to enoxaparin. Three patients were started on oral anticoagulation. There were no bleeding events. One patient expired, two were discharged from the hospital, and one continues hospitalized. DISCUSSION: There is growing evidence about the physiopathology, including descriptions of a proinflammatory state, disseminated intravascular coagulation, microthrombi and angiogenesis. Our patients had low-intermediate probability of PE based on Wells criteria, and intrinsically, COVID-19 represents an alternate diagnosis for hypoxemia and hypotension. It has been proposed that higher doses of prophylactic anticoagulation might be required, but no randomized controlled trial has been published. To protect healthcare workers and patients, usual diagnostic modalities might not be available. Furthermore, access to treatment options, such as catheter-directed thrombolysis might be limited. Systemic thrombolysis might be more feasible. CONCLUSIONS: Patients with COVID-19 with hemodynamically instability should be evaluated with advanced imaging for PE Systemic thrombolysis appears to be safe, but further studies are needed to establish the most adequate prophylaxis and treatment of thromboembolism in this population. Reference #1: Tang N, Bai H, Chen X, et al. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy. J Thromb Haemost 2020;18(5):1094–9. Reference #2: Ackermann M, Verleden SE, Kuehnel M, et al. Pulmonary vascular endothelialitis, thrombosis, and angiogenesis in Covid-19. N Engl J Med. DOI: 10.1056/NEJMoa2015432. DISCLOSURES: No relevant relationships by Amarilys Alarcon-Calderon, source=Web Response Consultant relationship with Bellerophon Please note: $1001 - $5000 Added 06/01/2020 by Roger Alvarez, source=Web Response, value=Travel Advisory Committee Member relationship with United Therapeutics Please note: $1001 - $5000 Added 06/01/2020 by Roger Alvarez, source=Web Response, value=Consulting fee No relevant relationships by Diego Celli, source=Web Response No relevant relationships by Jason Galo, source=Web Response No relevant relationships by Thomas Plate, source=Web Response